Disorders of Lipoprotein Metabolism Discussion

Disorders of Lipoprotein Metabolism Discussion
Select a disease of lipoprotein metabolism. Provide a brief review of the disorder, including a molecular and biochemical characterization as well as essential clinical features. Be sure to include relevant therapeutic strategies for managing the condition.
Genetic disorders of lipoprotein metabolism
Deepak Bhatnagar, … Handrean Soran, in Clinical Molecular Medicine, 2020
14.5 Diagnosing genetic disorders of lipoprotein metabolism
Most patients with primary disorders of lipoprotein metabolism are diagnosed incidentally when clinicians come across very high serum lipid concentrations or those with premature CHD. When challenged by a persistently poor lifestyle and diet, the body is generally able to limit the rise in serum lipids. However, depending on background population serum lipid levels, a serum cholesterol levels higher than 7.0 or 7.5 mmol/L or moderate-to-severe hypertriglyceridemia should raise the suspicion of a genetic disorder of lipoprotein metabolism. There are also certain signs (Table 14.2) [2] that point to the presence of a genetic disorder. However, it is important to note that in some secondary hyperlipidemias, serum lipid concentrations may be as high as those seen in primary hyperlipidemia. The coexisting secondary disorder is generally clinically apparent in such cases (Table 14.3) but may require other tests to establish the secondary cause.
Disorders of Lipid Metabolism
Clay F. Semenkovich, … Ira J. Goldberg, in Williams Textbook of Endocrinology (Thirteenth Edition), 2016
Disorders of Lipoprotein Metabolism Discussion
Familial Dysbetalipoproteinemia (Type III Hyperlipoproteinemia)
Familial dysbetalipoproteinemia (formerly known as type III hyperlipoproteinemia) is an uncommon disorder of lipoprotein metabolism that is characterized by moderate to severe hypertriglyceridemia and hypercholesterolemia caused by the accumulation of cholesterol-rich remnant particles in the plasma. Premature peripheral vascular disease and coronary artery disease are common. The cause is mutations in the apoE gene that result in defective binding of apoE to lipoprotein receptors. The disorder is associated with the apoE2 isoform and in most instances is inherited as an autosomal recessive trait. Because the phenotypic expression of the disorder is limited to approximately 1% of the patients with the apoE2/E2 phenotype, other genetic or environmental factors must also be operative. The hyperlipidemia is caused by a defect in clearance of remnant lipoproteins whose liver uptake requires apoE interaction with the LDL receptor, LRP1, and HSPG (see earlier discussion). The remnants that accumulate have lost much of their triglyceride through LPL-mediated triglyceride hydrolysis and therefore are cholesterol rich. The predominant remnant particles, termed ?-VLDL, can be identified by abnormal migration on gel electrophoresis or by abnormal lipid content.
Dysbetalipoproteinemia is usually diagnosed in adulthood and is rarely detected in persons younger than 20 years of age. The disorder is more common in men than in women. It is characterized by moderately severe elevations in plasma triglyceride and cholesterol levels; typically, these values both range from 300 to 400?mg/dL. Concentrations of HDL-C are normal. Xanthomas are present in more than half of affected subjects. Palmar xanthomas, which are planar xanthomas in the palmar creases (see Fig. 37-17F), are pathognomonic for this disorder. Tuberous or tuboeruptive xanthomas (see Fig. 37-17E) are also common but are less specific for this disorder. Tendon xanthomas and xanthelasma occur in some patients. Unlike FH, in which peripheral vascular disease is uncommon, premature peripheral vascular disease occurs in addition to premature coronary artery disease in patients with dysbetalipoproteinemia. Coexisting metabolic conditions that exacerbate the phenotype of dysbetalipoproteinemia, such as obesity, alcohol consumption, diabetes mellitus, and hypothyroidism, are often present.
In addition to homozygosity for the apoE2 isoform, some mutations in the apoE gene are known to lead to the dysbetalipoproteinemia phenotype in an autosomal dominant fashion. The phenotype manifests at an early age without exacerbating factors.

So much stress and so little time? Take care of yourself: let us help you with your task on
Disorders of Lipoprotein Metabolism Discussion
Get a 20% Discount on this Paper
Get Help Now
Calculate the price
Make an order in advance and get the best price
Pages (550 words)
$0.00
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
Sign up, place your order, and leave the rest to our professional paper writers in less than 2 minutes.
step 1
Upload assignment instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
s
Get personalized services with Do My Homeworkk
One writer for all your papers
You can select one writer for all your papers. This option enhances the consistency in the quality of your assignments. Select your preferred writer from the list of writers who have handledf your previous assignments
Same paper from different writers
Are you ordering the same assignment for a friend? You can get the same paper from different writers. The goal is to produce 100% unique and original papers
Copy of sources used
Our homework writers will provide you with copies of sources used on your request. Just add the option when plaing your order
What our partners say about us
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Finance
Wow! I should never have doubted you guys. Thank you for the excellent grade
Customer 452443, August 27th, 2021
Finance
Thank you
Customer 452445, September 8th, 2021
English 101
Great work!
Customer 452443, December 2nd, 2021
National Security Intelligence and Security Analysis
Timeliness
Customer 452457, November 3rd, 2021
Other
THANK YOU SO MUCH!
Customer 452493, May 16th, 2022
Other
Thank you!
Customer 452493, May 29th, 2022
Chemical Engineering
Amazing. The writer delivered the draft earlier than expected, lol. I am pleased with the work; I hope my supervisor will like it too.
Customer 452443, September 1st, 2021
Nursing
Excellent! Followed directions and completed a great paper
Customer 452445, August 22nd, 2021
Chemistry
Excellent services!
Customer 452443, November 11th, 2021
Finance
Excellent. Thnk you
Customer 452443, October 22nd, 2021
Philosophy
The paper was done to my satisfaction. Thnk you.
Customer 452443, November 18th, 2021
Economics
THANK YOU! :)
Customer 452493, April 12th, 2022
OUR GIFT TO YOU
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat

Order your essay today and save 15% with the discount code ESSAYHELP