BIOT 645 Abrilumab Monoclonal Antibody Paper

BIOT 645 Abrilumab Monoclonal Antibody Paper
This concise and articulate report written in prose (600 words) should include the following
MONOCLONAL:” ABRILUMAS ” Source of monoclonal (HUMAN)
Details of the antibody: what is the mechanism of action of this antibody
Commercialization: who is commercializing this antibody? What stage of development is the antibody at? Are any other companies also developing the same antibody? Is there any IP associated with the commercialization?
Manufacturing process: how is the antibody produced? Is it fully-humanized? What kind of yield is required every year? Are there any features which make this antibody difficult to produce in bulk?
Market details: how big is the market for this mAb? Are there multiple markets?
Regulatory details: what kind of regulatory approval is required for this mAb product?
Other applications: are there any other applications for this antibody?
Analysis: what do you think the long-term future of the antibody is? Does it have any other potential applications / indications?
Introduction of Abrilumab
Abrilumab (AMG 181/MEDI 7183) is a fully human monoclonal IgG2 antibody, like vedolizumab, against ?4?7 integrin designed for the treatment of inflammatory bowel disease, ulcerative colitis, and Crohn’s disease. Abrilumab was developed by MedImmune, and has been successively approved for marketing in Europe on December 11, 2015.
BIOT 645 Abrilumab Monoclonal Antibody Paper
Mechanism of Action of Abrilumab
The in?ammatory bowel diseases (IBDs) are chronic in?ammatory disorders of the GI tract consisting primarily of two subtypes, ulcerative colitis (UC) and Crohn’s disease (CD). CD is characterized by transmural in?ammation of any portion of the GI tract from mouth to anus, whereas UC is limited to the colon and rectum with in?ammation typically restricted to the mucosa, although in?ammatory involvement of the submucosa may occur in severe cases. Both CD and UC are characterized by an in?ux of in?ammatory cells, especially leukocytes into gut mucosal tissue. An important leukocyte involved in the pathogenesis of both CD and UC is the ?4?7-integrin-expressing T cell. Integrins, which consist of an ?- and ?-chain that together form a heterodimer, bind to ligands on endothelial cells, allowing leukocytes to firmly adhere to endothelial surfaces.
Extravasation of leukocytes from the blood into stromal tissues of gut mucosal tissue is a complex process involving a coordinated sequence of events between leukocytes and vascular endothelial cells. Several steps – tethering/rolling, activation, adhesion and extravasation/migration occur allowing immune cells to enter stromal tissues. Initially, leukocytes tether to the vascular endothelium through multiple transient interactions between selectins on leukocytes such as PSGL-1 and their ligands on the endothelial surface (P-selectin and E-selectin). This process decreases the speed of leukocytes to facilitate rolling along the endothelial surface. The slower speed of these leukocytes permits interactions to occur between integrins on the surface of the leukocyte and their ligands on the endothelium. Slowing leukocytes also allows chemokines from inflamed tissue to activate them resulting in leukocyte polarization, while also enhancing the binding affinity of integrins. When activated, these cells preferentially adhere to endothelial surfaces within the GI tract as well as the associated lymphoid tissues. Upon activation, ?4?7-integrin-expressing T cells bind to their ligand MAdCAM-1 and leukocytes are primed for extravasation. Leukocytes subsequently cross the endothelium and enter the mucosa through a paracellular route.
Abrilumab, sharing the same mechanism of Action with another monoclonal antibody—Vedolizumab, was also designed specifcally targets ?4?7, so that preventing the ?4?7/MAdCAM-1 interaction, hence inhibiting leukocyte migration into gut mucosa.

So much stress and so little time? Take care of yourself: let us help you with your task on
BIOT 645 Abrilumab Monoclonal Antibody Paper
Get a 20% Discount on this Paper
Get Help Now
Calculate the price
Make an order in advance and get the best price
Pages (550 words)
$0.00
*Price with a welcome 15% discount applied.
Pro tip: If you want to save more money and pay the lowest price, you need to set a more extended deadline.
We know how difficult it is to be a student these days. That's why our prices are one of the most affordable on the market, and there are no hidden fees.

Instead, we offer bonuses, discounts, and free services to make your experience outstanding.
Sign up, place your order, and leave the rest to our professional paper writers in less than 2 minutes.
step 1
Upload assignment instructions
Fill out the order form and provide paper details. You can even attach screenshots or add additional instructions later. If something is not clear or missing, the writer will contact you for clarification.
s
Get personalized services with Do My Homeworkk
One writer for all your papers
You can select one writer for all your papers. This option enhances the consistency in the quality of your assignments. Select your preferred writer from the list of writers who have handledf your previous assignments
Same paper from different writers
Are you ordering the same assignment for a friend? You can get the same paper from different writers. The goal is to produce 100% unique and original papers
Copy of sources used
Our homework writers will provide you with copies of sources used on your request. Just add the option when plaing your order
What our partners say about us
Check out the latest reviews and opinions submitted by real customers worldwide and make an informed decision.
Philosophy
The paper was done to my satisfaction. Thnk you.
Customer 452443, November 18th, 2021
National Security Intelligence and Security Analysis
Timeliness
Customer 452457, November 3rd, 2021
Nursing
Good work, professional and beat the deadline. Thank you so very much
Customer 452445, August 24th, 2021
Education
Looks good. Thank you!
Customer 452523, September 27th, 2022
Nursing
Looks good. Thank you!!!
Customer 452503, April 25th, 2022
Education
Awesome work, responded well and clarified everything.. Would definitely recommend, great service
Customer 452445, September 8th, 2021
Nursing
Great services.
Customer 452443, November 22nd, 2021
Business and administrative studies
Thank you so much for your help!!!!!
Customer 452519, November 9th, 2022
Economics
Although the paper did not make it at the requested time, the writer did reach out to me and asked for a short extension which I was okay with.
Customer 452493, March 16th, 2022
Finance
Excellent. Thnk you
Customer 452443, October 22nd, 2021
Other
Thank you!
Customer 452493, May 29th, 2022
Finance
Thank you
Customer 452445, September 8th, 2021
OUR GIFT TO YOU
15% OFF your first order
Use a coupon FIRST15 and enjoy expert help with any task at the most affordable price.
Claim my 15% OFF Order in Chat

Order your essay today and save 15% with the discount code ESSAYHELP