Assignment: Nutrition Research Methods

Assignment: Nutrition Research Methods ORDER NOW FOR CUSTOMIZED AND ORIGINAL ESSAY PAPERS ON Assignment: Nutrition Research Methods This is a Nutrition Research Methods Course (NUTR 670) The attached Word document contains the Homework 1 questions. You will also find a PDF research article and CONSORT checklist file that will be necessary to answer the questions. Assignment: Nutrition Research Methods Also, I attached all the PowerPoint slides that you MUST read and review before/during when you answering the questions PLUS watch the videos on the links below: https://www.ted.com/talks/stuart_firestein_the_pursuit_of_ignorance?language=en https://library.gmu.edu/tutorials/student-tutorials I need Correct, High quality and professional answers” Please, you MUST read and review all the Guidelines files which I attached before you start to answer the questions and you can use them while you answering the questions especially Questions 2 and 3. PLEASE, DO NOT use any British words and vocabularies, JUST the U.S. words. When you answer the question points in paragraphs way make sure that you answer all questions. If you feel that you can not do this homework as well professionally as exactly required, please, do not accept the order from the first second. Regards, consort_2010_checklist_1.doc nutr_670_homework_1_1.docx CONSORT 2010 checklist of information to include when reporting a randomised trial* Section/Topic Item No Checklist item Reported on page No Title and abstract 1a 1b Identification as a randomised trial in the title Structured summary of trial design, methods, results, and conclusions (for specific guidance see CONSORT for abstracts) 2a 2b Scientific background and explanation of rationale Specific objectives or hypotheses Interventions 3a 3b 4a 4b 5 Outcomes 6a Sample size 6b 7a 7b Description of trial design (such as parallel, factorial) including allocation ratio Important changes to methods after trial commencement (such as eligibility criteria), with reasons Eligibility criteria for participants Settings and locations where the data were collected The interventions for each group with sufficient details to allow replication, including how and when they were actually administered Completely defined pre-specified primary and secondary outcome measures, including how and when they were assessed Any changes to trial outcomes after the trial commenced, with reasons How sample size was determined When applicable, explanation of any interim analyses and stopping guidelines Introduction Background and objectives Methods Trial design Participants Randomisation: Sequence generation Allocation concealment mechanism Implementation Blinding CONSORT 2010 checklist 8a 8b 9 Method used to generate the random allocation sequence Type of randomisation; details of any restriction (such as blocking and block size). Assignment: Nutrition Research Methods Mechanism used to implement the random allocation sequence (such as sequentially numbered containers), describing any steps taken to conceal the sequence until interventions were assigned 10 Who generated the random allocation sequence, who enrolled participants, and who assigned participants to interventions If done, who was blinded after assignment to interventions (for example, participants, care providers, those 11a Page 1 Statistical methods Results Participant flow (a diagram is strongly recommended) Recruitment 11b 12a 12b Ancillary analyses 17b 18 Harms 19 For each group, the numbers of participants who were randomly assigned, received intended treatment, and were analysed for the primary outcome For each group, losses and exclusions after randomisation, together with reasons Dates defining the periods of recruitment and follow-up Why the trial ended or was stopped A table showing baseline demographic and clinical characteristics for each group For each group, number of participants (denominator) included in each analysis and whether the analysis was by original assigned groups For each primary and secondary outcome, results for each group, and the estimated effect size and its precision (such as 95% confidence interval) For binary outcomes, presentation of both absolute and relative effect sizes is recommended.Assignment: Nutrition Research Methods Results of any other analyses performed, including subgroup analyses and adjusted analyses, distinguishing pre-specified from exploratory All important harms or unintended effects in each group (for specific guidance see CONSORT for harms) Discussion Limitations Generalisability Interpretation 20 21 22 Trial limitations, addressing sources of potential bias, imprecision, and, if relevant, multiplicity of analyses Generalisability (external validity, applicability) of the trial findings Interpretation consistent with results, balancing benefits and harms, and considering other relevant evidence Other information Registration Protocol Funding 23 24 25 Registration number and name of trial registry Where the full trial protocol can be accessed, if available Sources of funding and other support (such as supply of drugs), role of funders Baseline data Numbers analysed Outcomes and estimation 13a assessing outcomes) and how If relevant, description of the similarity of interventions Statistical methods used to compare groups for primary and secondary outcomes Methods for additional analyses, such as subgroup analyses and adjusted analyses 13b 14a 14b 15 16 17a *We strongly recommend reading this statement in conjunction with the CONSORT 2010 Explanation and Elaboration for important clarifications on all the items. If relevant, we also recommend reading CONSORT extensions for cluster randomised trials, non-inferiority and equivalence trials, non-pharmacological treatments, herbal interventions, and pragmatic trials. Additional extensions are forthcoming: for those and for up to date references relevant to this checklist, see www.consort-statement.org. CONSORT 2010 checklist Page 2 Name __________________________ NUTR 670 Homework 1 (WEEKS 1,2,3,4,5 & 6) 1) Evaluating a Randomized Controlled Trial The following research article describes the use of a randomized controlled trial to evaluate the impact of adding lean red meat to a Mediterranean-style diet on risk factors for cardiometabolic disease (which includes cardiovascular disease). Assignment: Nutrition Research Methods O’Connor LE, Paddon-Jones D, Wright AJ, Campbell WW. A Mediterranean-style eating pattern with lean, unprocessed red meat has cardiometabolic benefits for adults who are overweight or obese in a randomized, crossover, controlled feeding trial. Am J Clin Nutr. 2018;108(1):33-40. doi:10.1093/ajcn/nqy075 Read the article and answer the following questions about it: a) Complete the CONSORT checklist by identifying where each item number appears in the published article. The checklist is included as a separate Word doc with the Homework. (We did not practice using the checklist in class, but we did talk about most of the items on the checklist. If you’re having trouble, I recommend reviewing the documents on the CONSORT website http://www.consort-statement.org, especially the “CONSORT 2010 Explanation and Elaboration Document”.) Upload your completed checklist with your homework submission. (15%) Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. b) Provide a critical review of the study. There is no specific formula to follow, but here are some items you may want to consider in your review; you may also find the CONSORT review to help in your review. I anticipate your review will be approximately 1 page, but can be longer. (30%) • • • • • • • Does the research design fit the stated purpose of the study? Have the authors included all relevant topics in the background? (Does the background information provide sufficient justification and rationale for this study? Have the authors omitted any relevant information to ‘spin’ their story?) Do you recognize any intolerable sources of bias in the study design? Are all major confounding variables controlled for in the study design? Are the methods of data collection appropriate for the study outcomes? Were the methodological limitations acknowledged and discussed? What influence might these limitations have on the results? • • • What is the real-world significance of these results, and (how) does this differ from the statistical significance? Are the authors’ conclusions supported by the data? Conclude with your overall assessment of what the impact of the study could/should be. Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. c) Using the information provided in the article, locate this trial on www.clinicaltrials.gov . Review this information; you’ll sometimes notice that there is some different information available on this website (or that the information is presented differently), as compared to the published peer-reviewed research article. Assignment: Nutrition Research Methods Describe any differences you observe, and if/how these differences impact your assessment of the published research article. (10%) Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. d) The authors provided a general hypothesis in their article, but they did not provide a fully conceived research question, null hypothesis, and alternative hypothesis as we have discussed at length in class. Re-write their research question, null hypothesis and alternative hypothesis according to the criteria discussed in class. (10%) Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. e) The authors chose a crossover study design for their RCT. Describe the advantages and disadvantages of using a crossover trial, as compared to a parallel arm design. Use specific examples from this study where possible in your answer. (10%) Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. (more on the next page) 2) Library Guest Lecture (10%) Name two library resources that Kathy Butler discussed that are available to you (other than Zotero) and provide a brief description of (1) what they are/do and (2) how they can be useful to you in your coursework and/or your future practice as a nutritionist. Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. 3) Nutrition Research Importance (15%) Imagine that you’re visiting with a family member or friend over the break, and they ask about your progress toward a nutrition degree. You naturally tell them that Nutrition Research Methods is your favorite class. Upon hearing this, they begin to complain about how they don’t appreciate that their tax dollars are being used to support nutrition research. After taking a deep breath and a moment to collect your thoughts, you respond by describing all the important reasons why nutrition research is important to our society and thus warrants spending public funds. Write that response here. Please type your answer here in blue (or some other bright color) text, so it’s easy for me to spot them. …Assignment: Nutrition Research Methods Get a 10 % discount on an order above $ 100 Use the following coupon code : NURSING10

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